Information Propagation in Time through Allosteric Signaling

Naively, one expects the information communicated by an enzyme downstream within a signaling network, in which is embedded, to grow monotonically with enzyme's rate of product formation. However, here we observe that this does not necessarily hold true for allosterically regulated enzymes, often observed networks. In particular, find mutual between catalytic sites and receiver protein pathway depends on transition kinetics different states their respective rates Surprisingly, our work implies allosteric down-regulation formation may only be used as way silence itself, would normally expect. Rather, also increase pathway.